Blar i forfatter "Hagen, Knut"

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    • Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI) 

      Husøy, Andreas Kattem; Håberg, Asta Kristine; Rimol, Lars Morten; Hagen, Knut; Vangberg, Torgil Riise; Stovner, Lars Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07)
      Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in volume, thickness, or surface area in the anterior cingulate cortex, prefrontal cortex, and insula. In addition, exploratory analyses on volume, thickness, and surface area across the ...

    • COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study 

      Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-16)
      Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults <40 years of age and can result in loss of life quality. Our aim was to explore the genetic background of DDH in order to improve diagnosis, management and longterm outcome.<p><p> ...

    • Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools 

      Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-17)
      Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five ...

    • Does insomnia modify the association between C-reactive protein and migraine? The Tromsø Study 2015-2016. 

      Hagen, Knut; Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Mathiesen, Ellisiv B.; Nilsen, Kristian Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-12)
      <p><i>Background - </i>The relationship between high sensitivity C-reactive protein and migraine is unclear. The aim of this cross-sectional population-based study was to investigate the association between high sensitivity C-reactive protein and types of headache, and to evaluate the impact of insomnia on this association. <p><i>Methods - </i>A total of 20,486 (63%) out of 32,591 invited, aged ≥40 ...

    • Pragmatiske studier – hva er det? 

      Lyngbakken, Magnus Nakrem; Paulsen, Aksel; Sethupathy, Ashwini; Hesselberg, Øyvind; Grimsgaard, Sameline; Hagen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-11)
      Konseptet pragmatiske studier ble foreslått av Schwartz og Lellouch i 1967 og problematiserte to viktige aspekter ved utprøving av ny behandling, nemlig forståelse og beslutning (1). Tradisjonelle forklarende effektstudier (explanatory trials) har som mål å øke vår forståelse ved å vise om en behandling virker per se, ofte under optimale forhold med nøye utvalgte studiedeltakere og utfallsmål. ...

    • Praktisk håndtering av hodepine 

      Aamodt, Anne Hege; Bjørk, Marte-Helene; Alstadhaug, Karl Bjørnar; Eldøen, Guttorm; Dueland, Aud Nome; Poole, Tine; Hagen, Knut; Vetvik, Kjersti; Ofte, Hilde Karen; Sønnervik, Julie; Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Lundqvist, Christofer; Sagabråten, Ståle Onsgår (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-03)
      Korrekt diagnostikk av ulike hodepinetyper kan være utfordrende, men det er den viktigste forutsetningen for optimal behandling. Det anbefales kontrollert bruk av anfallsmedisin og forebyggende tiltak.<p> <p>Hodepinesykdommer er ifølge sykdomsbyrdeprosjektet Global Burden of Disease blant de vanligste årsakene til funksjonsnedsettelse (1). Lidelsene påvirker i stor grad samfunnet, personene som ...